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Systems biology of pathogen‐host interaction: Networks of protein‐protein interaction within pathogens and pathogen‐human interactions in the post‐genomic era

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Systems biology of pathogen‐host interaction: Networks of protein‐protein interaction within pathogens and pathogen‐human interactions in the post‐genomic era

Auteurs : Saliha D. Durmu Tekir [Turquie] ; Kutlu Ülgen [Turquie]

Source :

RBID : ISTEX:5923D9035B663500401E122A1892DC2ED81B5263

English descriptors

Abstract

Infectious diseases comprise some of the leading causes of death and disability worldwide. Interactions between pathogen and host proteins underlie the process of infection. Improved understanding of pathogen‐host molecular interactions will increase our knowledge of the mechanisms involved in infection, and allow novel therapeutic solutions to be devised. Complete genome sequences for a number of pathogenic microorganisms, as well as the human host, has led to the revelation of their protein‐protein interaction (PPI) networks. In this post‐genomic era, pathogen‐host interactions (PHIs) operating during infection can also be mapped. Detailed systematic analyses of PPI and PHI data together are required for a complete understanding of pathogenesis of infections. Here we review the striking results recently obtained during the construction and investigation of these networks. Emphasis is placed on studies producing large‐scale interaction data by high‐throughput experimental techniques.
Pathogen‐host interactions (PHIs): Infectious microorganisms (pathogens) communicate with human cells through interactions with human proteins on the cell's surface as well as intracellular proteins. These interactions allow the microorganisms to enter the host cell and to manipulate cellular mechanisms in order to use the host cell's capabilities to their own advantage, resulting in infection in the host organism. This article reviews these networks, which may enable us to better elaborate the mechanisms of infection and to identify improved strategies to prevent or cure infectious diseases.

Url:
DOI: 10.1002/biot.201200110


Affiliations:


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<div type="abstract" xml:lang="en">Infectious diseases comprise some of the leading causes of death and disability worldwide. Interactions between pathogen and host proteins underlie the process of infection. Improved understanding of pathogen‐host molecular interactions will increase our knowledge of the mechanisms involved in infection, and allow novel therapeutic solutions to be devised. Complete genome sequences for a number of pathogenic microorganisms, as well as the human host, has led to the revelation of their protein‐protein interaction (PPI) networks. In this post‐genomic era, pathogen‐host interactions (PHIs) operating during infection can also be mapped. Detailed systematic analyses of PPI and PHI data together are required for a complete understanding of pathogenesis of infections. Here we review the striking results recently obtained during the construction and investigation of these networks. Emphasis is placed on studies producing large‐scale interaction data by high‐throughput experimental techniques.</div>
<div type="abstract" xml:lang="en">Pathogen‐host interactions (PHIs): Infectious microorganisms (pathogens) communicate with human cells through interactions with human proteins on the cell's surface as well as intracellular proteins. These interactions allow the microorganisms to enter the host cell and to manipulate cellular mechanisms in order to use the host cell's capabilities to their own advantage, resulting in infection in the host organism. This article reviews these networks, which may enable us to better elaborate the mechanisms of infection and to identify improved strategies to prevent or cure infectious diseases.</div>
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