Systems biology of pathogen‐host interaction: Networks of protein‐protein interaction within pathogens and pathogen‐human interactions in the post‐genomic era
Identifieur interne : 001A49 ( Main/Exploration ); précédent : 001A48; suivant : 001A50Systems biology of pathogen‐host interaction: Networks of protein‐protein interaction within pathogens and pathogen‐human interactions in the post‐genomic era
Auteurs : Saliha D. Durmu Tekir [Turquie] ; Kutlu Ülgen [Turquie]Source :
- Biotechnology Journal [ 1860-6768 ] ; 2013-01.
English descriptors
- Teeft :
- Acad, Annotation, Apoptosis, Bacillus anthracis, Bacillus subtilis, Bacteria gram, Bacterial pathogens, Bacterial proteins, Bacterial systems, Bioinformatic analyses, Biol, Biological pathways, Biotechnol, Biotechnology, Biotechnology journal biotechnol, Bottleneck proteins, Bronchial cells, Campylobacter jejuni, Cellular networks, Cellular processes, Chemical engineering, Coli, Comparative analysis, Complete understanding, Comprehensive analysis, Crucial roles, Database, Degree distribution, Drug discov, Escherichia, Escherichia coli, Escherichia coli bacteriophage, Essential proteins, Falciparum, First attempt, First examples, Focal adhesion, Francisella tularensis, Functional annotations, Gene ontology, Genome, Genome biol, Global analysis, Gmbh, Helicobacter pylori, Herpesviral protein networks, Host cells, Host factors, Host organism, Host organisms, Host proteins, Hostpathogen interactions, Human genes, Human genome, Human host factors, Human immunodeficiency virus, Human network, Human pathogens, Human proteins, Human proteome, Infection, Infection mechanisms, Infection strategies, Infectious diseases, Influenza, Influenza virus, Influenza virus replication, Interaction, Interaction data, Interaction network, Interaction networks, Interactome, Interactome maps, Intraviral, Intraviral ppis, Jejuni, Kaposi herpesvirus, Kgaa, Kshv, Literature mining, Molecular interactions, Multiple species, Multiprotein complexes, Mycobacterium tuberculosis, Natl, Nature genet, Novel interactions, Nucleic, Nucleic acids, Other hand, Other members, Other organisms, Pathogen, Pathogenesis, Pathogenesis mechanisms, Pathogenic, Pathogenic microorganisms, Pathogenic organisms, Pathway, Pestis, Pestis proteins, Phi, Plo, Plos pathog, Ppis, Proc, Protein, Protein complexes, Protein functions, Protein interaction, Protein interaction network, Protein interactions, Protein kinase, Protein networks, Proteome, Proteome organization, Public databases, Pylorus, Recent years, Replication, Respiratory syndrome coronavirus, Rnai screen, Saccharomyces cerevisiae, Saliha durmus tekir, Significant amount, Similar behavior, Smallest genomes, Striking results, Syphilis spirochete, Systematic analysis, Systems biology, Topological properties, Treponema pallidum, Unannotated proteins, Uncharacterized, Uncharacterized proteins, Vaccine targets, Vaccinia, Vaccinia virus, Verlag, Verlag gmbh, Viral, Viral networks, Viral pathogens, Viral proteins, Viral replication, Virus, Virus gram, Weinheim, Weinheim biotechnol, Whole proteome, Yersinia pestis.
Abstract
Infectious diseases comprise some of the leading causes of death and disability worldwide. Interactions between pathogen and host proteins underlie the process of infection. Improved understanding of pathogen‐host molecular interactions will increase our knowledge of the mechanisms involved in infection, and allow novel therapeutic solutions to be devised. Complete genome sequences for a number of pathogenic microorganisms, as well as the human host, has led to the revelation of their protein‐protein interaction (PPI) networks. In this post‐genomic era, pathogen‐host interactions (PHIs) operating during infection can also be mapped. Detailed systematic analyses of PPI and PHI data together are required for a complete understanding of pathogenesis of infections. Here we review the striking results recently obtained during the construction and investigation of these networks. Emphasis is placed on studies producing large‐scale interaction data by high‐throughput experimental techniques.
Pathogen‐host interactions (PHIs): Infectious microorganisms (pathogens) communicate with human cells through interactions with human proteins on the cell's surface as well as intracellular proteins. These interactions allow the microorganisms to enter the host cell and to manipulate cellular mechanisms in order to use the host cell's capabilities to their own advantage, resulting in infection in the host organism. This article reviews these networks, which may enable us to better elaborate the mechanisms of infection and to identify improved strategies to prevent or cure infectious diseases.
Url:
DOI: 10.1002/biot.201200110
Affiliations:
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<term>Host organisms</term>
<term>Host proteins</term>
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<front><div type="abstract" xml:lang="en">Infectious diseases comprise some of the leading causes of death and disability worldwide. Interactions between pathogen and host proteins underlie the process of infection. Improved understanding of pathogen‐host molecular interactions will increase our knowledge of the mechanisms involved in infection, and allow novel therapeutic solutions to be devised. Complete genome sequences for a number of pathogenic microorganisms, as well as the human host, has led to the revelation of their protein‐protein interaction (PPI) networks. In this post‐genomic era, pathogen‐host interactions (PHIs) operating during infection can also be mapped. Detailed systematic analyses of PPI and PHI data together are required for a complete understanding of pathogenesis of infections. Here we review the striking results recently obtained during the construction and investigation of these networks. Emphasis is placed on studies producing large‐scale interaction data by high‐throughput experimental techniques.</div>
<div type="abstract" xml:lang="en">Pathogen‐host interactions (PHIs): Infectious microorganisms (pathogens) communicate with human cells through interactions with human proteins on the cell's surface as well as intracellular proteins. These interactions allow the microorganisms to enter the host cell and to manipulate cellular mechanisms in order to use the host cell's capabilities to their own advantage, resulting in infection in the host organism. This article reviews these networks, which may enable us to better elaborate the mechanisms of infection and to identify improved strategies to prevent or cure infectious diseases.</div>
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